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TSC Alert

What does “single-blind” or “double-blind” mean?

“Blinding” is a procedure in which one or more persons in the research trial are kept unaware of the treatment assignment(s).  Single-blind usually means that the research participant is not told of the treatment assignment.   Double-blind usually means that the research participant, investigator, study coordinator/nurse, study sponsor, and in some cases the data analyst are kept unaware of the treatment assignment.  The purpose of a “blinded” study design is to remove the unintentional bias that can affect the interpretation of the research information that is collected, if the treatment assignment is known.