Grants and Funding
New Funding Opportunity for Hypothesis-Driven Research in 2021!
TSC Newborn Screening (NBS) Assay Development Funding Opportunity Announcement
The goal of this funding opportunity announcement (FOA) is to take the first steps to identify a biomarker (or combination of biomarkers) for TSC detectable in dried blood spots from infants through targeted (hypothesis-driven) experiments or non-targeted metabolomic or proteomic profiling. Because this FOA is funding only the first steps, the proposed research may utilize, but is not required to utilize, dried blood spots. However, the approach should ultimately be adaptable to dried blood spots with additional work.
NBS Program Priorities
Applications must address one of the two recommendations from the Innovation Workshop or, if proposing an alternative approach, the application must justify the rationale for an alternative approach, and the applicant should discuss the idea with TSC Alliance staff in advance.
- Research (e.g., metabolomics or proteomics) to identify a biomarker or a panel of biomarkers which may be unique for TSC in dried blood spots from infants, recognizing that future funding and work would be required to develop a specific assay for the candidate biomarker(s).
- Research to develop and test the viability of an assay to detect a 50% decrease of hamartin or tuberin in blood of infants with TSC.
Unless the applicant can demonstrate compatibility with existing NBS technology in use by states, genetic sequencing or other genetic approaches will not be funded.
TSC Alliance Innovation Workshop Grants support research that aims to address the Program Priorities in this FOA and are not intended to act as a funding stream to continue the projects previously supported by the TSC Alliance.
The TSC Alliance is providing a Newborn Screening Toolkit of biosamples available in the TSC Biosample Repository and other resources of which we are aware. If you know of additional relevant resources we should include, please email us at email@example.com and we will update the toolkit.
|Online portal opens||Friday, July 16, 2021|
|Letter of Intent (LOI) Due||Monday, August 23, 2021|
|Applications Due||Monday, September 13, 2021|
|Award Start Date||Wednesday, December 1, 2021|
TSC Alliance Research Grants Program
The TSC Alliance endeavors to stimulate, support and coordinate research that will lead to a cure for tuberous sclerosis complex (TSC) while improving the lives of those affected. Most TSC Alliance research grants support small, focused projects that allow investigators to develop preliminary data to compete for funding from larger organizations such as the National Institutes of Health (NIH). Other TSC Alliance research grants support postdoctoral fellowships to encourage young investigators to engage in TSC research. Many of these investigators will continue to pursue TSC research when they establish their own independent laboratories.
Researchers funded by the TSC Alliance have a strong history of obtaining additional funding: between 1984 and 2020, principal investigators who received a total of $27.7 million from the TSC Alliance subsequently garnered an additional $17.8 million from the Department of Defense’s Tuberous Sclerosis Complex Research Program and $465 million from the NIH.
2021 Research Grants Cycle In Process – Sign up for TSC Alert to be first to know about the 2022 cycle
In 2021 we anticipate awarding one or two postdoctoral fellowships and one or two research grants, depending on merit, requested budgets, and funds available. A description of research funded previously is available below.
|Online submission for letters of intent (LOI) opens||Friday, March 19, 2021|
|LOIs due||Monday, May 17, 2021|
|Full proposal invitations distributed||Friday, June 25, 2021|
|Full proposals due (by invitation only)||Monday, August 23, 2021|
|Earliest project start date||Wednesday, December 1, 2021|
Important Changes from Previous Cycles
- Applicants for either a Postdoctoral Fellowship or a Research Grant must fit the NIH definition of an Early-Stage Investigator (this change was implemented in 2020).
- Postdoctoral Fellowship applicants must have been a member of the Sponsor’s laboratory for at least 12 months as of the Letter of Intent due date.
- Previous recipients of a TSC Alliance Postdoctoral Fellowship are not eligible to receive a second TSC Alliance Postdoctoral Fellowship but may be eligible to receive a Research Grant as an independent, early-stage investigator.
- Emphasis on mentoring and anticipated impact of receiving a Postdoctoral Fellowship on the applicant’s career plans.
- The TSC Alliance will work diligently to diversify applications by actively seeking and increasing applications from institutions and researchers underrepresented in TSC research. To measure our progress, applicants will be asked to voluntarily provide information on race, ethnicity, and gender via the Professional Profile in ProposalCentral. This information will be used internally by TSC Alliance and will not be shared with peer reviewers.
Types of Grants
- Postdoctoral Fellowship awards may support any type of basic or translational research relevant to TSC that provides an outstanding opportunity for the trainee’s professional growth.
- Postdoctoral Fellowship awards are intended to provide funding for an individual who has recently earned a PhD or MD degree and is working with a Sponsor to perform research relevant to TSC.
- The Sponsor must be tenure-track faculty or an equivalent level at a research institution or company. The award is intended to fund the applicant’s salary and some of the laboratory supplies or tools necessary to conduct the proposed research. The award is not intended to fund technical support for the project or to purchase equipment in the Sponsor’s laboratory. The trainee applicant is considered to be the “Principal Investigator” for the purpose of postdoctoral fellowship awards.
- Research Grant proposals should address one of the following four high-priority areas:
- Understanding phenotypic heterogeneity in TSC, i.e., research on genetic, biologic, or environmental factors that might explain why TSC is so different from person to person
- Gaining a deeper knowledge of TSC signaling pathways and the cellular consequences of TSC deficiency
- Improving TSC disease models, whether cell-based, tissue-based, or animal models
- Developing clinical biomarkers or patient-reported outcome measures for TSC, particularly those that assess disease burden or stratify an individual’s risk of progression or developing specific manifestations of TSC
- Research Grant awards are intended to provide funding for an independent researcher, whether tenure-track faculty, non-tenure-track faculty or staff, or an equivalent level at a research institution or company. The award may support laboratory supplies, personnel costs, services, or equipment necessary to conduct the proposed research.
- The TSC Alliance fully supports collaborative projects between co-investigators, but only one investigator may be considered the “Principal Investigator” for the purpose of applying through the online system.
Duration and Budget
- Typical duration is two years. Can be shorter if appropriate for the project.
- Maximum total costs of $75,000 per year ($150,000 total).
- Postdoctoral Fellowship proposals must include up to $1,500 for travel expenses to attend a relevant scientific meeting. This is optional but strongly encouraged for Research Grant proposals.
For research grants, including postdoctoral fellowships, the TSC Alliance allows no more than 10 percent of the total costs to be applied to indirect costs. As an example, a maximum of $15,000 indirect costs may be included within an award totaling $150,000.
This opportunity is open to all investigators at established academic or research institutions or at pharmaceutical or biotech companies worldwide. Researchers residing in the United States do not need to be U.S. citizens to apply for funding.
Additional Grant Policies
- TSC Alliance Intellectual Property Policy
- TSC Alliance Human and Animal Use Policy
- TSC Alliance Policy on the Use of Human Fetal Tissue and/or Human Embryonic Stem Cells in Research
- TSC Alliance Open Science Policy
Keith Hall Research Grant Award
The Keith Hall Research Grant Award was established in memory of Keith Hall, an adult with TSC and a former TSC Alliance board chair and community leader. Keith participated extensively in several TSC Alliance volunteer capacities and was a “gentle giant” to so many people who knew him. Keith passed away July 23, 2017 after a battle with cancer and left an incredible legacy of caring for others and inspiring hundreds of children, teens and adults with TSC to embrace life and live it to the fullest, despite any challenges they may face. Keith’s major long-term concerns and goals included:
- Addressing the needs of adults with TSC
- Living with kidney involvement
- Increasing participation to the TSC Natural History Database
- Donating tissue for research
- Making involvement in clinical trials easy for anyone
- Investing in TSC research grants
Each year, the TSC Alliance Board of Directors designates one grant in an area of Keith’s interest as the Keith Hall Research Grant Award.
Current and Previous Grant Awards
Other TSC Funding Opportunities
Additional funding opportunities for TSC research may be available through the federal agencies and non-federal organizations listed below. The TSC Alliance also looks to collaborate with other organizations that have shared research priorities and are interested in partnering or co-funding opportunities.
If you would like to add your organization to the list below or are interested in the possibility of exploring co-funding opportunities, please contact Steve Roberds.
For Inquiries, Contact:
Science Project Manager