Apart from the physical manifestations of tuberous sclerosis complex (TSC), most people with TSC are affected by a broad range of behavioral, psychiatric, intellectual, academic, neuropsychological and psychosocial difficulties. Examples include autism, ADHD, intellectual disability, anxiety and depressive disorders, and difficulties in scholastic skills. These problems often cause the greatest burden to individuals with TSC and their families.
The Neuropsychiatry Panel of the International TSC Consensus Conference in 2012 realized there was a big gap in the identification and treatment of these difficulties. To reduce this ‘identification gap’ they created the term ‘TAND,’ which stands for TSC-associated neuropsychiatric disorders.