“The TSC Alliance and the Preclinical Consortium have been instrumental partners in establishing the preclinical models and data necessary for development of our candidate therapeutic. The historical data sets, knowledge of the models, and connection with the CROs running the models have helped guide our team about what constitutes a successful treatment, and we are optimistic for the path forward.”
Patrick Sarmiere, VP of Preclinical Development, Ovid Therapeutics
The TSC Preclinical Consortium is a partnership with TSC researchers in industry and academia, designed to facilitate the evaluation of novel and repurposed therapeutics for their effectiveness and safety in animal models of TSC. The goal is to advance those therapeutics with compelling effectiveness and safety are advanced to clinical trials.
The Preclinical Consortium approach
Directed by Dean Aguiar, PhD, (Vice President, Translational Research) who has more than 20 years in drug design from his previous work in pharma and scientific foundations, the consortium delivers quality in drug testing by:
- Ensuring the reproducibility of models and assays
- License negotiation and management
- Study oversight for quality control
- Data interpretation assistance
The different manifestations of TSC — such as tumors kidneys as well as epilepsy — are modeled in mice using different genetic manipulations. We also have many murine biospecimens held at our repository at the Van Andel Institute including liver, kidney, brain and plasma.
Epilepsy and behavior
- Capability for 24/7 EEG monitoring and analysis with our partner contract research organization, PsychoGenics, Inc.
- On-demand breeding at the same facility as EEG
- Longitudinal tumor volume measurement and other assays done with our partner contract research organization, Porsolt
- On-demand breeding at the same facility
The Preclinical Consortium has unique ability to bring on additional models and assays to meet the research needs of our partners. We achieve this transgenic work through our partnership with the Van Andel Institute.
For inquiries, contact:
The TSC Preclinical Consortium is coordinated and wholly funded by the TSC Alliance thanks to generous support from the Gerry and Bill Cowlin Foundation, Drs. Bonnie and Jonathan Rothberg & Family, and many additional donors through the Unlock the Cure campaign. Company Members also support the Consortium through membership fees.
The TSC Alliance is proud to partner with the following Contract Research Organizations to conduct our studies.