Autism-like cluster recommendations

• Everyone with TSC should be monitored for symptoms in the autism-like cluster from early in infancy and throughout adulthood.
• Anyone who shows behaviors within the autism-like cluster should be referred for a formal clinical evaluation for autism or communication delay.
• As there is no research on treating autism-like cluster symptoms in people with TSC, we suggest that the evidence from research with children and adults with autism without TSC may be relevant to those with TSC.
• Young children with autism and TSC may benefit from naturalistic developmental behavioral interventions (NDBI) and other evidence-based supports for children with autism.
• Adults with TSC and autism-like cluster symptoms may benefit from recognized autism interventions such as social skills training.
• As there are often high rates of co-occurring physical, developmental, and mental health problems in people with symptoms in the autism-like cluster, we recommend lifelong monitoring for any co-occurring conditions, followed by appropriate treatment.
• Even though autism (and the autism-like cluster) is the most extensively researched cluster in TSC, much more research is needed, especially regarding non-medical treatments in individuals with TSC.