Dysregulated behavior cluster recommendations

• Dysregulated behaviors are common in TSC, have a major impact on the family and require a systematic approach.
• It is important to understand the meaning/function of dysregulated behaviors to guide intervention.
• It is also important to understand the intellectual and neuropsychological profile to inform the meaning/function of dysregulated behaviors and to guide intervention.
• Perform urgent physical work-up for sudden onset of dysregulated behavior and/or rapid change in behaviors.
• Use non-pharmacological intervention strategies as first-line treatment for dysregulated behaviors.
• Medications should be used after a careful systematic evaluation and always alongside a non-pharmacological intervention plan.
• Research is required to generate a TSC-specific evidence base for non-pharmacological interventions of dysregulated behaviors.