TSC2 Mutations Alter Brain Development Earlier Than Previously Understood
New research shows that TSC2 mutations may disrupt brain development at very early stages by changing the genome’s output through altered DNA methylation and gene regulation in neural progenitor cells. Using patient-derived stem cells, researchers found that TSC2-mutant cells developed abnormally
Read More: TSC2 Mutations Alter Brain Development Earlier Than Previously Understood
Apertura Gene Therapy and the TSC Alliance Announce Collaboration to Advance Gene Therapy Programs Designed to Treat TSC
Apertura Gene Therapy, a biotechnology company developing next-generation AAV ca...
Read More: Apertura Gene Therapy and the TSC Alliance Announce Collaboration to Advance Gene Therapy Programs Designed to Treat TSC
Simufilam Improves Seizure Outcomes in a Mouse Model of Tuberous Sclerosis Complex
A new study found that simufilam, an experimental oral drug, reduced seizure pr...
Read More: Simufilam Improves Seizure Outcomes in a Mouse Model of Tuberous Sclerosis Complex
Checkpoint Kinase Inhibitors Halt Growth of TSC2-Deficient Kidney Tumors in Preclinical Models
Checkpoint kinase (CHK1/2) inhibitors may offer a promising new treatment strate...
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Study Links Sleep Problems in Tuberous Sclerosis Complex to Overactive mTOR and Orexin Signaling
A novel study led by Michael Wong, MD, PhD, suggests that sleep disturbances in ...
Read More: Study Links Sleep Problems in Tuberous Sclerosis Complex to Overactive mTOR and Orexin Signaling
Study Explores Similarities between Tuberous Sclerosis Complex and Alzheimer’s Disease
This study investigates a brain disorder called tuberous sclerosis complex (TSC)...
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Research Reveals Extracellular Vesicles as Promising Biomarkers for Tuberous Sclerosis Complex
A new study has found that extracellular vesicles (EVs)—tiny, cell-derived par...
Read More: Research Reveals Extracellular Vesicles as Promising Biomarkers for Tuberous Sclerosis Complex
Study Identifies Key Inflammatory Biomarkers Linked to Epilepsy in Tuberous Sclerosis Complex
A new study has identified a distinct inflammatory signature in people with tube...
Read More: Study Identifies Key Inflammatory Biomarkers Linked to Epilepsy in Tuberous Sclerosis Complex
Understanding the Role of Macrophages in Lymphangioleiomyomatosis (LAM)
In a recent study, researchers investigated the immune microenvironment in Lymph...
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Impact of SUDEP on Mortality in Tuberous Sclerosis Complex
Two recent papers looked at distinct sources of data to understand causes of pre...
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Understanding Disclosure of Tuberous Sclerosis Complex to Romantic Partners
This research paper explores the complex issue of disclosing a tuberous sclerosi...
Read More: Understanding Disclosure of Tuberous Sclerosis Complex to Romantic PartnersEpilepsy Surgery in Tuberous Sclerosis Complex: A Real-World Study
This research paper presents a comprehensive study on epilepsy surgery outcomes ...
Read More: Epilepsy Surgery in Tuberous Sclerosis Complex: A Real-World StudyUnderstanding the Impact of Seizures on Development in Tuberous Sclerosis Complex
In a recently published study, researchers found that accumulated seizure burden...
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Searching for Blood-based Biomarkers for Kidney Angiomyolipoma and Cysts in Tuberous Sclerosis Complex
Newly published research shows the feasibility of finding blood-based methods to...
Read More: Searching for Blood-based Biomarkers for Kidney Angiomyolipoma and Cysts in Tuberous Sclerosis ComplexUnderstanding Tuberous Sclerosis Complex Through Phenotypic Clustering
In a new study using the TSC Alliance’s Natural History Database, researchers ...
Read More: Understanding Tuberous Sclerosis Complex Through Phenotypic ClusteringThe role of the TSC Alliance in advancing therapy development: a patient organization perspective
Finding a new treatment for any disease is a long and expensive process, and it ...
Read More: The role of the TSC Alliance in advancing therapy development: a patient organization perspective