Validation of the self-report quantified Tuberous Sclerosis Complex-Associated Neuropsychiatric Disorders Checklist (TAND-SQ)
Tuberous sclerosis complex (TSC) can affect behavior, emotions, learning, memory, attention, sleep, and family life. Together, these challenges are called TSC-associated neuropsychiatric disorders, or TAND. Most people with TSC experience
Read More: Validation of the self-report quantified Tuberous Sclerosis Complex-Associated Neuropsychiatric Disorders Checklist (TAND-SQ)
A Scaled Approach to Resolve TSC2 Variants of Unknown Significance
When a person is tested for tuberous sclerosis complex (TSC), doctors look at th...
Read More: A Scaled Approach to Resolve TSC2 Variants of Unknown Significance
Mapping the Cells Inside TSC Brain Tumors
SEGAs Are a Serious Concern for TSC Patients Many people with tuberous scleros...
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A New Way to Care for Adults With Developmental Disabilities
Many people with conditions like autism or intellectual disability receive speci...
Read More: A New Way to Care for Adults With Developmental DisabilitiesTSC2 Mutations Alter Brain Development Earlier Than Previously Understood
New research shows that TSC2 mutations may disrupt brain development at very...
Read More: TSC2 Mutations Alter Brain Development Earlier Than Previously Understood
Apertura Gene Therapy and the TSC Alliance Announce Collaboration to Advance Gene Therapy Programs Designed to Treat TSC
Apertura Gene Therapy, a biotechnology company developing next-generation AAV ca...
Read More: Apertura Gene Therapy and the TSC Alliance Announce Collaboration to Advance Gene Therapy Programs Designed to Treat TSC
Simufilam Improves Seizure Outcomes in a Mouse Model of Tuberous Sclerosis Complex
A new study found that simufilam, an experimental oral drug, reduced seizure pr...
Read More: Simufilam Improves Seizure Outcomes in a Mouse Model of Tuberous Sclerosis Complex
Checkpoint Kinase Inhibitors Halt Growth of TSC2-Deficient Kidney Tumors in Preclinical Models
Checkpoint kinase (CHK1/2) inhibitors may offer a promising new treatment strate...
Read More: Checkpoint Kinase Inhibitors Halt Growth of TSC2-Deficient Kidney Tumors in Preclinical Models
Study Links Sleep Problems in Tuberous Sclerosis Complex to Overactive mTOR and Orexin Signaling
A novel study led by Michael Wong, MD, PhD, suggests that sleep disturbances in ...
Read More: Study Links Sleep Problems in Tuberous Sclerosis Complex to Overactive mTOR and Orexin Signaling
Study Explores Similarities between Tuberous Sclerosis Complex and Alzheimer’s Disease
This study investigates a brain disorder called tuberous sclerosis complex (TSC)...
Read More: Study Explores Similarities between Tuberous Sclerosis Complex and Alzheimer’s Disease
Research Reveals Extracellular Vesicles as Promising Biomarkers for Tuberous Sclerosis Complex
A new study has found that extracellular vesicles (EVs)—tiny, cell-derived par...
Read More: Research Reveals Extracellular Vesicles as Promising Biomarkers for Tuberous Sclerosis Complex
Study Identifies Key Inflammatory Biomarkers Linked to Epilepsy in Tuberous Sclerosis Complex
A new study has identified a distinct inflammatory signature in people with tube...
Read More: Study Identifies Key Inflammatory Biomarkers Linked to Epilepsy in Tuberous Sclerosis Complex
Understanding the Role of Macrophages in Lymphangioleiomyomatosis (LAM)
In a recent study, researchers investigated the immune microenvironment in Lymph...
Read More: Understanding the Role of Macrophages in Lymphangioleiomyomatosis (LAM)Impact of SUDEP on Mortality in Tuberous Sclerosis Complex
Two recent papers looked at distinct sources of data to understand causes of pre...
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Understanding Disclosure of Tuberous Sclerosis Complex to Romantic Partners
This research paper explores the complex issue of disclosing a tuberous sclerosi...
Read More: Understanding Disclosure of Tuberous Sclerosis Complex to Romantic PartnersEpilepsy Surgery in Tuberous Sclerosis Complex: A Real-World Study
This research paper presents a comprehensive study on epilepsy surgery outcomes ...
Read More: Epilepsy Surgery in Tuberous Sclerosis Complex: A Real-World StudyUnderstanding the Impact of Seizures on Development in Tuberous Sclerosis Complex
In a recently published study, researchers found that accumulated seizure burden...
Read More: Understanding the Impact of Seizures on Development in Tuberous Sclerosis Complex
Searching for Blood-based Biomarkers for Kidney Angiomyolipoma and Cysts in Tuberous Sclerosis Complex
Newly published research shows the feasibility of finding blood-based methods to...
Read More: Searching for Blood-based Biomarkers for Kidney Angiomyolipoma and Cysts in Tuberous Sclerosis ComplexUnderstanding Tuberous Sclerosis Complex Through Phenotypic Clustering
In a new study using the TSC Alliance’s Natural History Database, researchers ...
Read More: Understanding Tuberous Sclerosis Complex Through Phenotypic ClusteringThe role of the TSC Alliance in advancing therapy development: a patient organization perspective
Finding a new treatment for any disease is a long and expensive process, and it ...
Read More: The role of the TSC Alliance in advancing therapy development: a patient organization perspective