Sclerotic bone lesions are commonly observed in individuals with tuberous sclerosis complex (TSC) when high-resolution chest computed tomography (CT) is performed as surveillance for possible lymphangioleiomyomatosis (LAM) or abdominal magnetic resonance imaging (MRI) is performed as surveillance for renal angiomyolipoma.


These bone lesions are common and relatively specific for TSC. It is important that clinicians understand that these lesions are not surprising in TSC and rarely require intervention, and they should not raise undue alarm of possible cancer.

Reviewed by Ashley Pounders, MSN, FNP-C, Director of Medical Affairs, TSC Alliance, November 2023.

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