TSC Research Matters Archive - TSC Alliance

Anita Bhatia Foundation for Tomorrow Renews Commitment to TSC and TAND Research

The Anita Bhatia Foundation for Tomorrow marks the next chapter in a philanthropic journey built on years of impact through the Ramesh and Kalpana Bhatia Family Foundation. Grounded in a legacy of

Finding the Answers to Improve TAND Outcomes

Agnies van Eeghen, MD, PhD, says caring for individuals with tuberous sclerosis ...

Checkpoint Kinase Inhibitors Halt Growth of TSC2-Deficient Kidney Tumors in Preclinical Models

Checkpoint kinase (CHK1/2) inhibitors may offer a promising new treatment strate...

Michael Wong, MD, PhD: A Life Dedicated to TSC Clinical Care, Research, and Philanthropy

With a career in tuberous sclerosis complex (TSC) spanning more than 20 years, M...

Study Links Sleep Problems in Tuberous Sclerosis Complex to Overactive mTOR and Orexin Signaling

A novel study led by Michael Wong, MD, PhD, suggests that sleep disturbances in ...

Navigating the Diagnostic Journey: What Families Face After a Tuberous Sclerosis Complex Diagnosis

When a child is diagnosed with tuberous sclerosis complex (TSC)—a genetic diso...

Seeking Targeted Behavioral Strategies for TSC – Shafali Spurling Jeste, MD

Shafali Spurling Jeste, MD, a child neurologist and Chair of the Department of P...

TSC and Neurodegenerative Diseases: A Conversation with Andy Liu, MD, MS

Tuberous sclerosis complex (TSC) is a genetic condition due to mutations in T...

Study Explores Similarities between Tuberous Sclerosis Complex and Alzheimer’s Disease

This study investigates a brain disorder called tuberous sclerosis complex (TSC)...

Notes from a TSC Mom

Blair Simon opens up about how TSC has affected not just her son, Jacob, but the...

Fierce Advocates for Life-Changing Research – Lesley and Alex Holmes

Lesley and Alex Holmes were thrilled when they learned Lesley was pregnant with ...

Exploring New Frontiers of Research on TAND – Elizabeth Thiele, MD, PhD

After twenty years running the Herscot Center for Tuberous Sclerosis Complex at ...

Research Reveals Extracellular Vesicles as Promising Biomarkers for Tuberous Sclerosis Complex

A new study has found that extracellular vesicles (EVs)—tiny, cell-derived par...

Study Identifies Key Inflammatory Biomarkers Linked to Epilepsy in Tuberous Sclerosis Complex

A new study has identified a distinct inflammatory signature in people with tube...

Mitigating Risk: Family Planning and TSC

When Danielle was diagnosed with TSC, it came as a shock. She had made it to her...

Why I give: Philanthropy with a Businessman’s Touch

David Coit’s journey to becoming a dedicated member of the TSC Alliance was bo...

Harnessing the Immune System to Fight TSC and LAM

Elizabeth P. Henske, MD The Henske laboratory at Brigham and Women’s Hospital ...

Understanding the Role of Macrophages in Lymphangioleiomyomatosis (LAM)

In a recent study, researchers investigated the immune microenvironment in Lymph...

Impact of SUDEP on Mortality in Tuberous Sclerosis Complex

Two recent papers looked at distinct sources of data to understand causes of pre...

Understanding Disclosure of Tuberous Sclerosis Complex to Romantic Partners

This research paper explores the complex issue of disclosing a tuberous sclerosi...

Epilepsy Surgery in Tuberous Sclerosis Complex: A Real-World Study

This research paper presents a comprehensive study on epilepsy surgery outcomes ...

Why I Give: This Warrior Grandma is All In

When she learned that her infant granddaughter, Isabel, might have tuberous scle...

Kinsley’s Story

Bailey Green was determined to give her daughter Kinsley the best life possible,...

Derek Bauer, MD: Giving Voice to the Adult Experience of TSC

Derek Bauer, MD, has a unique connection to the individuals he cares for at the ...

Understanding the Impact of Seizures on Development in Tuberous Sclerosis Complex

In a recently published study, researchers found that accumulated seizure burden...

Why We Give: A Passion for Research

Stephanie and Tom McCann watched helplessly as their infant daughter, Claire, su...

2025 TSC International Research Conference: Forging new discoveries

The 2025 TSC International Research Conference: Engage, Accelerate, Transform wa...

Living His Dream: Bear plays Banana-ball

The TSC Alliance is working to create a future where everyone affected by sclero...

Carmen Priolo: Chasing drug targets and metabolic biomarkers for TSC

After years working in the cancer field, scientist Carmen Priolo, MD, PhD, disco...

TSC Research Changes Lives: Rosy’s Story

Rosy was just four months old when she was diagnosed with tuberous sclerosis com...

Brendan Manning: Unraveling the cell’s inner workings

For Brendan Manning, PhD, today’s advances in basic science are the stepping s...

Searching for Blood-based Biomarkers for Kidney Angiomyolipoma and Cysts in Tuberous Sclerosis Complex

Newly published research shows the feasibility of finding blood-based methods to...

Understanding Tuberous Sclerosis Complex Through Phenotypic Clustering

In a new study using the TSC Alliance’s Natural History Database, researchers ...

Why I give: For Helen and others like her

When Brittany Smith learned that her infant daughter Helen had tuberous sclerosi...

The role of the TSC Alliance in advancing therapy development: a patient organization perspective

Finding a new treatment for any disease is a long and expensive process, and it ...

The Reason for Giving: Honey Amado

Micah Amado was born in 1984 with a quick wit and a kind heart. His mother, Hone...

TSC Research Changes Lives: Amaan’s Story

When Noor and Zohra Panjwani learned their infant son Amaan had tuberous scleros...

A conversation with Steve Roberds, PhD

TSC Alliance Chief Scientific Officer Steve Roberds, PhD, leads the development ...

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