A new open access paper in the Journal of the American Academy of Dermatology investigates fibrous cephalic plaques (FCPs) in individuals with TSC. The authors found that though clinicians typically look for FCPs on the forehead, roughly 60% of FCPs are found on the neck, scalp, or elsewhere on the face. Clinicians who find FCPs should recognize them as a potential sign of TSC and evaluate the patients further.

FCPs are a major diagnostic feature of TSC according to the guidelines developed at the 2012 TSC Consensus Conference. FCPs and one other major feature of TSC (or FCPs and two or more minor features) are sufficient to make a definite diagnosis of TSC.

Oyerinde O, Buccine D, Treichel A, Hong C, Lee CCR, Moss J, Darling TN. Fibrous cephalic plaques in tuberous sclerosis complex. J Am Acad Dermatol. 2018;78(4):717-724. doi: 10.1016/j.jaad.2017.12.027.