The Tuberous Sclerosis Complex Research Program (TSCRP) is now accepting Pre-Applications for the fiscal year 2020 grant cycle.

Three award mechanisms are available this year:

The deadline to submit a Pre-Application Letter of Intent is June 18, 2020 at 5 pm Eastern. A brief summary of the three award mechanisms and submission requirements can be found here.

The mission of the FY20 TSCRP is to fund exploratory, pioneering, and transformative science that promotes discoveries in TSC, from mechanistic insights to clinical application across the lifespan, by supporting new ideas and investigators for the benefit of Service members, their beneficiaries, and the American public. Within this context, the FY20 TSCRP encourages applications in mechanistic and patient-centered studies that focus on one of the following Focus Areas:

  • Eradicating tumors associated with TSC and TSC-associated lymphangioleiomyomatosis (LAM), including gaining a deeper mechanistic understanding of TSC signaling pathways
  • Preventing epilepsy, improving treatment, and mitigating comorbidities associated with TSC-related seizures
  • Understanding the features of TSC-Associated Neuropsychiatric Disorders (TAND) and reducing their impact, including pharmacological and behavioral interventions
  • Advancing clinical trial readiness and optimizing clinical care through development of biomarkers and clinical outcome measures, patient selection and sample size determination, pharmacokinetic/pharmacodynamics (PK/PD) studies, and enhanced trial design

If the proposed research project does not address one or more of the FY20 TSCRP Focus Areas, justification that the proposed research project addresses an important problem or unmet need related to TSC research and/or patient care should be provided.

The TSCRP is part of the Congressionally Directed Medical Research Programs (CDMRPs) at the United States Department of Defense. Please see the TSCRP website for more information on these three funding mechanisms.